Anabolic Steroids Profile - Equipoise

Anabolic Steroids Profile - Equipoise
Equipoise was actually created while attempting to make a product which would be be a long acting injectable d-bol (Methandrostenolone). What was actually created was a product which, in the real world acts nothing like D-bol, despite it´s similarity to it chemically. A simple way to think of Equipoise, chemically at least, is simply as Dianabol without the 17-alpha-methyl group (that´s the thing which makes D-bol able to be ingested orally and not be destroyed by your liver). However, having had first hand experience with both Equipoise as well as D-bol, I can tell you that the results from each are vastly different.
To make Equipoise, a double bond was added between carbon atoms 1 and 2 of the Steran Nucleus of Testosterone. What does this mean? Well, first of all, since Equipoise was created by one simple modification in the testosterone molecule, you could rightly suspect that it shares many similarities with it. Equipoise is just as anabolic as testosterone (as you can tell by its anabolic rating above), but only half as androgenic. Those ratings can be quite deceiving though, as I don´t know anyone who would claim that you can gain as much weight on Equipoise as you can gain on an equal amount of testosterone (even though strength gains from the two compounds are very similar).
It´s not very common to compare Equipoise to testosterone; however& a far more common comparison is between Equipoise and Deca. I suspect this is because when Dan Duchaine introduced this compound to the steroid using community, he made an immediate comparison to Deca, speculating that it would act similarly to Deca but like a much stronger version of it. Equipoise doesn´t actually act much like deca at all; Deca is actually a progestin and a 19-nor derived steroid whereas Equipoise is more closely related to testosterone (being only one double bond differ rent). Duchaine later rescinded his original statement on Equipoise and said that it was disappointing as a mass builder when compared with deca, but a far better drug than for both strength gains and vascularity. Unfortunately, the myth that Equipoise´s action is similar to Deca´s has persisted for nearly 2 decades after he revised his opinion; this is most evident on internet message boards today, where many will advise against including both of them in a cycle because "they act the same way."
The 1-2 double bond that Equipoise has is responsible for many of its characteristics. First of all, it acts to slow aromatization (conversion into estrogen). The best estimate is that it does so at roughly half the rate of testosterone (1). This is the best number I´ve found in studies. Athletes almost never report estrogenic side effects with Equipoise, even when the dose is up to a gram per week. Side effects caused by estrogen include oily skin, acne, and gynocomastia, and as I said, those are usually not found from Equipoise. Virilization (development of male sexual characteristics in women) is almost never seen with this compound, when reasonable doses are used by female athletes. This is one of the few injectable compounds which could be successfully be used by female athletes and bodybuilders, and isn´t often faked.
Clinical Equipoise and AthletesThat double bond is also responsible for Equipoise´s resistance for being changed by the 5- 5-Alpha-reductase enzyme (2)(3). This enzyme converts a small amount of Boldenone into Dihydroboldenone, which is a very potent androgen (7x as anabolic as testosterone)(4). As I said though, such a small amount of it is converted that it´s really of no concern to most athletes taking Equipoise. This factor, plus its low aromatization rate mean athletes don´t need to consider using ancillaries with Equipoise.
Athletes taking Equipoise often report a slow and constant buildup of quality muscle, and certainly this has been my experience with the drug. I would speculate that this slow buildup of muscle is due to the very long ester attached to the Boldenone; Undeclynate is a longer ester than the decanoate ester by one carbon. Thus, we could expect the accumulation of muscle from Equipoise to actually occur at a slightly slower rate than that found with Deca (nandrolone decanoate). This leads me to advise that if you are considering the use of Equipoise, you should consider using it for no less than 12 weeks. Equipoise, like deca, is also detectable in your system for a long time (although it is substantially less than deca´s detection time).
Strangely, shorter estered versions of Boldenone are available as well. Anecdotally, many people (and manufacturers) claim that this produces less water retention...but water retention from Equipoise is virtually unheard of, so I consider this to be a silly idea.
An informal poll I took on Steroid.com (as well as with my friends) seems to put the ideal dose of Equipoise at 600mgs/week. Most people I asked about their Equipoise experience with Equipoise seemed to think that using over 600mgs/week produced no additional results, but the jump from 400mgs/week to 600mgs/week produced noticeable additional gains, and thus was warranted. I have personally found very nice results from 400mgs-600mgs/week myself.
Equipoise Side EffectsOne of the most pronounced effects in Equipoise is its ability to raise your RBC´s (red blood cells). This is very typical of anabolic steroids; however, Equipoise would appear to do it to a slightly greater degree than most. One of the other effects most Equipoise users report is an increased appetite. I can say that this is true of me, also; this factor makes it impossible for me to diet on it. It´s because of this ability to increase appetite that many will include Equipoise in a mass cycle, and it´s for the quality of muscle gained on it that many will include it in a cutting cycle. It´s probably the most versatile injectable compound, next to testosterone. People even use a low dosed version of Equipoise to blend with irritating injectable drugs suck as testosterone suspension or Propionate. I´m thinking of the old Ganabol version which was dosed at 50mgs/ml, here... it´s not that Equipoise is especially good to cut other steroids with, but the low dose and cost of Ganabol made it ideal to do this with, when sterile oil wasn´t available or desirable. This low dosed version was also very popular with women, who were comfortable shooting 1cc of this stuff every few days or every week.
Equipoise will cause a suppression of your hormones, such as endogenous testosterone, so I would also recommend using injectable testosterone in any cycle containing it. Failure to do so could result in possible sexual dysfunction and other sides.
Buy EquipoiseFinally, when you buy equipoise, one of the best parts of Equipoise is it´s low price and high availability. Equipoise is produced by most Underground Labs at very reasonable prices. You shouldn´t be paying more than $50 for a 10cc bottle dosed at 200mgs/ml, and that price is true of Mexican veterinary products and underground labs alike.
I´d have to say that due to its incredible versatility, availability, and low price, Equipoise is going to be a staple in many cycles for a long time.

Cialis

Anabolic Steroids Profile Cialis (Tadalafil Citrate) Cialis vs. Viagra Cialis (Tadalifil citrate) is the second-generation Viagra, more or less. While the little blue pill may work to give you an erection for 6-8 hours, Cialis is good for 36-48 hours. This obviously makes it much more practical. Why are we talking about this? Well I doubt anyone using endogenous testosterone would need to consider the use of such a compound, this drug can still have some uses during post-cycle therapy. A lot of men find that once they go off steroids and begin post cycle therapy (PCT), they suffer reduced libido as well as erectile dysfunction. Well, Cialis may be useful for helping this, at least during PCT. The efficacy and safety of Tadalafil for the treatment of erectile dysfunction was assessed in a 6-month study. Men with mild, moderate or severe ED were given tadalafil (20 mg) as needed or placebo ("any minute now, baby no, really& "). Tadalafil significantly improved erectile function compared with placebo (which only succeeded in embarrassing the men who took it and tried to get laid). At the end of the study, sexual intercourse attempts success rate for those using Cialis was 73.5% (this only refers to the ability to achieve erection and have intercourse, not the actual success rate of those attempting to get laid on a given night)(1). Cialis Side Effects Of particular interest to those considering the use of Cialis is that Lack of sexual activity due to erectile dysfunction actually decreases testosterone (T) levels through a central effect on the hypothalamic-pituitary axis.(2) Cialis was given to men for a month, and at the end, they had considerably higher testosterone levels, because they got laid more(2), as it is unlikely that the drug has a different direct effect on the pituitary-testis axis. This stuff is actually very safe, and was even given 3x a week to men (1) for an extended length of time, and was well tolerated, had very few sides, and was very effective (1). Thus, it could be another potential compound for inclusion in PCT. Tadalafil (20 mg) significantly improves erectile function, could increase testosterone, and is well tolerated (3), certainly something to think about after your next cycle. References: A 6-month study of the efficacy and safety of tadalafil in the treatment of erectile dysfunction: a randomised, double-blind, parallel-group, placebo-controlled study in Australian men. Int J Clin Pract. 2005 Feb;59(2):143-9. Type V phosphodiesterase inhibitor treatments for erectile dysfunction increase testosterone levels. Clin Endocrinol (Oxf). 2004 Sep;61(3):382-6. Efficacy and treatment satisfaction with on-demand tadalafil (Cialis) in men with erectile dysfunction. Eur Urol. 2004 Sep;46(3):362-9; discussion 369.

Cytadren

Cytadren
Aminoglutethimide
Cytadren (Aminoglutethimide) is one of the more interesting compounds found in the bodybuilder´s arsenal of Ancillaries. It´s really not too popular today, but a decade or two ago, it was considered state of the art, and was prized by bodybuilders for many of it´s properties.

Lets first consider it´s primary use, which is that of an Anti-Estrogenic compound. is able to produce highly significant (almost total) estrogen suppression (1), and this is of course of interest to athletes who are using steroids which convert to estrogen. Unfortunately, this suppression of estrogen is not followed by an increase in any of the other hormones (testosterone, LH, FSH, etc... ) that many other anti-estrogenic compounds will cause. Thus, Cytadren is probably not going to be anyone´s first choice for use in Post-Cycle-Therapy.

The thing which, in my mind, sets it apart from other ancillary compounds currently in use today is its unique ability to inhibit the production of cortisol. Cortisol, as you recall, is a catabolic hormone, and breaks down muscle. Cytadren inhibits the conversion of cholesterol to pregnenolone (2) as well as having an aromatase inhibiting effect. Thus, Cytadren is quite unique in having both of these abilities, and certainly none of the AI´s I´ve seen thus far has anything resembling such an effect on cortisol.

Cytadren is used, medically, to fight breast cancer and/or hyperadrenocorticism, and it is the only drug currently available (to my knowledge) that can be used successfully for both purposes (1)(3). It may even have anti-depressive properties (4)(5). During a cycle, it may be used to both lower cortisol levels from intense training, and to lower estrogen levels. Sounds almost perfect, right? It´s use would allow us to consider the use of Arimidex, Nolvadex, or a similar compound for strictly post cycle use, when an increase in test, LH, and FSH would be more necessary...

Well, it´s not quite perfect, as you´ll soon see. The first problem is that it (possibly) could reduce androgen levels. The best we could hope for is that it doesn´t have much of an effect on circulating androgen levels (1).

The next problem is that eventually your body, smart cookie that it is, will start to figure out ways to compensate for the reduction in cortisol, by either producing more, or inhibiting the Cytadren´s effects. Great... And while the cortisol isn´t present in your body, your joints will be aching. Yeah, I´ve actually used this stuff (the things I do in the name of science!), and it worked& made me look a bit "dryer" and more cut; but as I recall, it also made me sleepy. This could be due to its effects on the adrenal cortex, I don´t really know, but that´s a pretty good guess.

If you are thinking about using Cytadren for this purpose, I´d have to tell you to forget it. Three grams of Vitamin C lowers your Cortisol around as much as 1,000mgs of Cytadren, from the literature I´ve seen on both, and the Vitamin C doesn´t do it at the expense of your adrenal responsiveness (7). A gram of Vitamin C lowered cortisol by 1/3rd in UltraMarathon Competitors (8) (these are the people who apparently don´t have cars, so they feel compelled to run 90 kilometers at a time). I just can´t justify taking Cytadren for an extended period of time to reduce cortisol, when Vitamin can do the same thing, more cheaply, and has other added benefits.

Next, we have to deal with Cytadren´s liver toxicity (3). This stuff is pretty stressful on your liver. I guess we can use some milk thistle and such, but do we really want to risk it, when it´s effects on cortisol are short lived and it may reduce circulating androgen levels?

Maybe...

See you can use this stuff for (maybe) the last week or so while you are dieting for a bodybuilding contest, when your circulating androgens are being totally replaced by synthetic androgens, and you aren´t giving your adrenal-cortex much chance to shut down and make you lethargic, then I think it may be useful. Taking 500mgs/day for your last week of contest prep may help you to dry out that last little bit, and edge out that ever increasing specter of cortisol over production for long enough to do dial in for your contest. For athletes considering this compound in their cycles, I think this is not a viable option when you consider all of the other available options.

References:

Preservation of androgen secretion during estrogen suppression with aminoglutethimide in the treatment of metastatic breast carcinoma. J Clin Invest. 1980 March; 65(3): 602 612.
Adrenocortical steroidogenesis and aminoglutethimide I. Biomedical studies. Biomedicine. 1973 May;18(3):185-91.
Use of aminoglutethimide in the treatment of pituitary-dependent hyperadrenocorticism in the dog. J Small Anim Pract. 2002 Mar;43(3):104-8.
Treatment of depression with antiglucocorticoid drugs.Psychosom Med. 1999 Sep-Oct;61(5):698-711.
Neuroendocrine responses to inhibitors of steroid biosynthesis in patients with major depression resistant to antidepressant therapy.Can J Psychiatry. 1998 Apr;43(3):279-86.
Treatment of metastatic breast cancer with aminoglutethimide.Cancer. 1981 Apr 15;47(8):1954-8.
A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress. Psychopharmacology (Berl). 2002 Jan;159(3):319-24. Epub 2001 Nov 20.
Attenuation of increase in circulating cortisol and enhancement of the acute phase protein response in vitamin C-supplemented ultramarathoners.Int J

Stanozolol Winstrol

Winstrol
Stanozolol Winstrol - Stanozolol is a very commonly used anabolic steroid for cutting cycles. While many people will attempt to use Dianabol or even Anadrol for cutting cycles, I´ve really never heard of anyone using Stanozolol for anything except a cutting cycle. It´s a bit of a one-trick-pony in this respect. Let me repeat that: Stanozolol is a cutting drug. Not many people will argue for its use in a bulking cycle. It´s certainly not a very effective compound for treating anemia (1) and thus, one could rightly assume that its role in bulking cycles is very limited. One novel use for Winstrol in any cycle (perhaps even bulking) would be to use it at a very limited dose, in order to lower SHBG. (2) One of the properties of Winstrol is it´s profound ability to lower SHBG much more than other steroids. A dose of .2mg/kg lowered SHBG significantly, which would in turn, raise the amount of free testosterone circulating in the body. As with 99% of steroids, however, it´s important to note that suppression of your natural hormonal levels will occur (though perhaps not to the extent that it will with many other steroids).(10) As with running virtually any compound, testosterone supplementation (i.e. running test in a cycle containing Winstrol) is warranted to avoid possible sexual dysfunction. Winstrol & Stanozol Side EffectsAdding it to a heavy bulking cycle could be problematic, as Stanozolol is a 17aa compound, meaning that it´s been altered to endure the first pass through your liver without being destroyed. This makes it an orally active compound; so many people choose to take the pills which are available from both legitimate pharmaceutical companies as well as Underground Labs. Unfortunately, since it is 17aa, it is also liver toxic& in fact; Stanozolol has one of the worst hepatoxicity (mg for mg) of any steroid. This is the reason its addition to a bulking cycle could be problematic; generally a bulking cycle will be very heavy, dosage wise as well as toxicity-wise. It also has undesirable results on Cholesterol, and a mere 6mgs/day of Stanozolol can lower HDL by 33% and raise LDL by 29% (3). Cardiac Hypertrophy, even at lower doses could be a concern with Winstrol as well (4) Thus, many people limit their intake of Stanozolol to precontest or Summer-cutting types of cycles. It´s generally accepted that due to the toxicity issues of Stanozolol, its use should be limited to 6 weeks& as with anything though, many people have run it for up to 12 weeks with no problems. Winstrol & Stanozol Use Effects I ran Winstrol for about 3 months (12 weeks) at a dose of 100mgs Every Other Day (along with Test prop at 125mgs, every other day) and I suffered no ill-effects. My joints felt fine, and I can say that the only thing which was undesirable about that cycle was the injection pain. Generally, people report a "dry" and less lubricated feeling in their joints when on this drug (fluid retention is nil with Stanozolol), and also a "dry" overall look as regards contest prep. This could be due to a sort of "reverse-osmotic" effect...of course this is speculation, but people do look "dryer" on Winnie, and some even look dryer in the site they inject (more on this later). There are many conflicting reports on tendon strength and Stanozolol, even in medical journals. Some reports state that it weakens tendons, others that it strengthens them (and some speculation on the internet among many "guru´s" is that it strengthens them unevenly, leading to possible injury). For this reason, it may be best for athletes in explosive or high-impact sports to stay away from this drug. It has certainly been shown to be beneficial in some bone ailments induced by glucocorticoid induced stress (5) as well as having collagen producing properties (11), but with all of the anecdotal problems athletes have suffered with their joints while on Stanozolol, I simply can not recommend it with confidence to strength/speed athletes. I can say that personally, it was an effective compound for me and did not cause joint duress, but I can do without the discomfort of the shots, and have found other DHT based compounds to be far more effective (Masteron springs to mind). As previously stated, this compound is unique, as it is available in both an oral form as well as an injectable form. Both forms contain the exact same compound, but injecting this compound (and yes, you can drink the injectable version, and no you shouldn´t) is superior to ingesting it orally in terms of nitrogen retention (6), and thus one would also imagine, for overall anabolism. Injecting it also has the advantage of avoiding the "first pass" through your liver, and thus places your liver under less stress. Stanozolol (Winstrol) and WomenStanozolol is also one of the few compounds that women can take safely, as it´s anabolic:androgenic ratio is quite skewed towards anabolism. It´s generally accepted that women can tolerate around 5-10mgs a day of this compound. Men, on the other hand can dose themselves in the .5-1.5mg/kg range. I find 100mgs injected every other Day to be sufficient, but of course, even with the injectable form, every day dosing is optimal. I tend to favor DHT based compounds, and have enjoyed great success with a Winstrol/Masteron/Testosterone cycle, but I suspect that replacing the Masteron in that cycle with Trenbolone would prove more beneficial for most bodybuilders seeking to get ripped. Although the anabolic ratio of this product is very high as compared to its androgenic actions, not many people report huge weight gains off of Stanozolol. Also, interestingly, it has a relatively weak AR binding ability (7), which is quite unusual for a "cutting" steroid. Many of the effects of this drug, as relates to building muscle, are probably from its very high protein synthesizing ability (6) (8). In addition, since this compound is derived from DHT, it tends to promote a very nice, "quality" look to the user´s muscles, with little or no water retention. Winstrol does not aromatize at any rate and has even been speculated to have anti-progestenic properties (in at least some cases, where it may "block" that receptor) (9). If one were to run ancillary compounds with Stanozolol, perhaps Tamoxifen would be appropriate for it´s beneficial effects on blood lipids, but an anti-estrogen (in it´s classic sense) would be unwarranted; proper post cycle therapy is still needed, though. Most underground labs produce Winstrol at very reasonable prices, in both an oral as well as injectable form. Unfortunately, production value differs vastly due to the varying size of the Stanozolol powder used to make the injectable version; the finer the powder, the smaller gauge needle it will fit through, and the easier the injection will be. Of course the opposite is also true& In any case, you should be paying under $100 for a 10ml bottle of 100mg/ml concentration, and roughly the same for 100 or so 10mg tablets. Winstrol ProfileStanozolol [17beta-Hydroxy-17-methyl-5alpha-androstano[3,2-c]pyrazole] Molecular Weight: 344.5392 Molecular Formula: C22H36N2O Melting Point:N/A Manufacturer: (Originally) Sterling Release Date:1962 Effective Dose(men): 50-100mgs/day Effective Dose (women): 2.5-10mgs/day Active Life:8hours Detection Time:3 weeks (oral) to 9 weeks (injectable) Androgenic/Anabolic Ratio:30:320 References: Trop Doct. 2004 Jul;34(3):149-52. J Clin Endocrinol Metab. 1989 Jun;68(6):1195-200 JAMA. 1989 Feb 24;261(8):1165-8. J Steroid Biochem Mol Biol. 2005 Jan;93(1):43-8. Epub 2005 Jan 25. Di Yi Jun Yi Da Xue Xue Bao. 2003 Nov;23(11):1117-20. Can J Vet Res. 2000 Oct;64(4):246-8. Endocrinology. 1984 Jun;114(6):2100-6. J Am Vet Med Assoc. 1997 Sep 15;211(6):719-22 Agents Actions. 1994 Mar;41(1-2):37-43. Chemical Muscle Enhancement J Invest Dermatol. 1998 Dec;111(6):1193-7.

Nolvadex (Tamoxifen Citrate)

Nolvadex (Tamoxifen Citrate) Buy Nolvadex (Tamoxifen Citrate) Nolvadex is a drug commonly referred to as an anti-estrogen. This would suggestless or no estrogen is produced due to the drug's actions as in the case of Teslac. Actually,Nolvadex is an estrogen antagonist, meaning it competes with estrogen at estrogenreceptor- sites. This prevents the active estrogen from entering its receptor and creatingan estrogenic complex capable of activity. Since many AAS aromatize (covert toestrogen) to some degree, the control of feminizing side effects (males should payattention here) is important. Males normally have a very low estrogen level. During AAScycles, due to aromatization, estrogen levels rise considerably. This elevated estrogenlevel can cause feminizing side effects such as increased fat deposits, water retention, andgynecomastia (growth of breast gland tissue and painful tumors under the nipple). As arule, it is more the ratio of androgens-to-estrogens than the simple increase in estrogenthat actually initiates feminizing side effects. It is important that the reader realizes that Nolvadex does not decrease estrogenproduction and that it simply blocks estrogen receptors. For this reason the suddendiscontinuance of Nolvadex will allow the increased level of circulating estrogen tomerge with the newly freed receptors and do feminine things to the body. "Enter Proviron". At the end of a steroid cycle, the body's natural testosteroneproduction can be impaired. Due to the aromatization of the AAS estrogen levels aresignificantly higher than normal and Nolvadex only helps by blocking the estrogenreceptors. If an athlete abruptly ends an AAS protocol without regeneration of the HPTAunder these conditions, much of the hard earned gains would disappear due to estrogenbecoming the dominant hormone. So what did the boys (that didn’t want to be a girl) do? Proviron is an anti-estrogen (*See "Proviron" for more info) that helps to preventestrogen production while elevating androgen levels. During the last week of an AAScycle, some male bodybuilders began a HCG protocol (*See HCG) and administered 25-mg Proviron/10-20-mg Novladex 1-2 times daily. This was commonly noted to almostcompletely suppress post-cycle estrogen and its activity. Since Nolvadex increases thebody's own testosterone production, as does HCG, much of the cycle gains were retainedquite well. Nolvadex has a direct effect on the hypothalamus and therefore increases therelease of Gonadotropic hormones to a minor degree. (The hormones that tell the Leydigcells in the testes to produce androgens such as testosterone are refereed to asGonadotropics) Many added Clomid (*See Clomid) to their post-cycle stacks beginning6-10 days after HCG and continued for the average reported two week duration. In mostcases the result was athletes with normal (or above) sex drive and androgen production! * High dosage use of Nolvadex can inhibit natural testosterone production. This is due toinhibition of enzymes needed for testosterone production by the testes. Nolvadex was normally layered into any protocol utilizing high aromatizing steroids suchas testosterone, Dianabol, or those that are progesterone receptor stimulators such asAnadrol-50. Those who were prone to high fat deposits, water retention, and gynoconsistently reported inclusion of Nolvadex. Many are were to obtain excellent estrogenicactivity suppression with only 10-mg daily while others noted the need for as much as60-mg daily (20mg 3 times daily). The best results and guidelines were obtained bystarting low and increasing dosages only when necessary. It is important for the reader to realize that AAS must have some estrogen presentin order to achieve their full positive potential effectiveness and provide the bestcommonly desired results. This is why many AAS lose their anabolic qualities whencombined with anti-estrogens. It is also why Methandriol magnifies the effects of thesame AAS. Those who used high anabolic/moderate-low androgenic steroids such asnandrolones, Primobolan, or Winstrol, and did not combine them with high aromatizingsteroids (such as testosterone) often considered not using Nolvadex during cycles the bestchoice when increased mass was the primary intent. Women who used Nolvadex usually did so because it aids in fat loss due to lessestrogenic activity. I have yet to see a female compete whom was able to achieve trulycut legs with out it. Women athletes often combined 10-20mg of Nolvadex with 50-75mgProviron daily for the last few weeks of dieting. Due to availability of Clenbuterol,Proviron dosages were reported lower as of late, at least in female fitness competitors.Women should be aware that birth control is an estrogen and Novladex will block itseffectiveness. Women have note irregular menstrual cycles, weaker menstrual bleeding,and sometimes skip periods all together during Nolvadex use. I know several women whouse Nolvadex for this reason and can not say I disagree with their choice. After all, theuse of progestin type birth control as a means of regulating or even stopping menstruationis becoming accepted in the medical circles at last. A few athletes have experienced a paradox when using high dosages of Nolvadex.Instead of lowering estrogenic activity, it increased it. What happened was that theAdrenal glands went into over drive producing a pro-hormone called DHEA. DHEA isactually an adrenal androgen normally secreted in lower levels. As circulating levelsincreased enzymic factors came into play. Research shows DHEA readily converts intoandrostenedione, and to some extent, estrogens in males. (That sucks!) The femaleendocrine system usually favors testosterone production from converted DHEA orandrostenedione. The newly formed estrogen then overwhelmed the estrogen receptorsblocking the intended qualities of Novladex. In this case, Proviron, and especially Teslacwhere notably better choices. *Gyno that fails to react to these drugs normally must be removed by surgery. DHTderivatives can cause increases endogenous estrogen production also in some individuals.Cytadren was a commonly co-administered drug with Nolvadex. Reported Characteristics Active-Life: Less than 24 hours Drug Class: Anti-estrogen/estrogen antagonist (Oral) Average Reported Dosage: 10-30-mg daily Acne: None Water Retention: No High Blood Pressure: Rare (not normally attributed to the drug itself) Liver Toxic: Yes

Nolvadex (Tamoxifen Citrate)

Nolvadex (Tamoxifen Citrate)
Buy Nolvadex (Tamoxifen Citrate)
Nolvadex is a drug commonly referred to as an anti-estrogen. This would suggestless or no estrogen is produced due to the drug's actions as in the case of Teslac. Actually,Nolvadex is an estrogen antagonist, meaning it competes with estrogen at estrogenreceptor- sites. This prevents the active estrogen from entering its receptor and creatingan estrogenic complex capable of activity. Since many AAS aromatize (covert toestrogen) to some degree, the control of feminizing side effects (males should payattention here) is important. Males normally have a very low estrogen level. During AAScycles, due to aromatization, estrogen levels rise considerably. This elevated estrogenlevel can cause feminizing side effects such as increased fat deposits, water retention, andgynecomastia (growth of breast gland tissue and painful tumors under the nipple). As arule, it is more the ratio of androgens-to-estrogens than the simple increase in estrogenthat actually initiates feminizing side effects.
It is important that the reader realizes that Nolvadex does not decrease estrogenproduction and that it simply blocks estrogen receptors. For this reason the suddendiscontinuance of Nolvadex will allow the increased level of circulating estrogen tomerge with the newly freed receptors and do feminine things to the body.
"Enter Proviron". At the end of a steroid cycle, the body's natural testosteroneproduction can be impaired. Due to the aromatization of the AAS estrogen levels aresignificantly higher than normal and Nolvadex only helps by blocking the estrogenreceptors. If an athlete abruptly ends an AAS protocol without regeneration of the HPTAunder these conditions, much of the hard earned gains would disappear due to estrogenbecoming the dominant hormone. So what did the boys (that didn’t want to be a girl) do?
Proviron is an anti-estrogen (*See "Proviron" for more info) that helps to preventestrogen production while elevating androgen levels. During the last week of an AAScycle, some male bodybuilders began a HCG protocol (*See HCG) and administered 25-mg Proviron/10-20-mg Novladex 1-2 times daily. This was commonly noted to almostcompletely suppress post-cycle estrogen and its activity. Since Nolvadex increases thebody's own testosterone production, as does HCG, much of the cycle gains were retainedquite well. Nolvadex has a direct effect on the hypothalamus and therefore increases therelease of Gonadotropic hormones to a minor degree. (The hormones that tell the Leydigcells in the testes to produce androgens such as testosterone are refereed to asGonadotropics) Many added Clomid (*See Clomid) to their post-cycle stacks beginning6-10 days after HCG and continued for the average reported two week duration. In mostcases the result was athletes with normal (or above) sex drive and androgen production!
* High dosage use of Nolvadex can inhibit natural testosterone production. This is due toinhibition of enzymes needed for testosterone production by the testes.
Nolvadex was normally layered into any protocol utilizing high aromatizing steroids suchas testosterone, Dianabol, or those that are progesterone receptor stimulators such asAnadrol-50. Those who were prone to high fat deposits, water retention, and gynoconsistently reported inclusion of Nolvadex. Many are were to obtain excellent estrogenicactivity suppression with only 10-mg daily while others noted the need for as much as60-mg daily (20mg 3 times daily). The best results and guidelines were obtained bystarting low and increasing dosages only when necessary.
It is important for the reader to realize that AAS must have some estrogen presentin order to achieve their full positive potential effectiveness and provide the bestcommonly desired results. This is why many AAS lose their anabolic qualities whencombined with anti-estrogens. It is also why Methandriol magnifies the effects of thesame AAS. Those who used high anabolic/moderate-low androgenic steroids such asnandrolones, Primobolan, or Winstrol, and did not combine them with high aromatizingsteroids (such as testosterone) often considered not using Nolvadex during cycles the bestchoice when increased mass was the primary intent.
Women who used Nolvadex usually did so because it aids in fat loss due to lessestrogenic activity. I have yet to see a female compete whom was able to achieve trulycut legs with out it. Women athletes often combined 10-20mg of Nolvadex with 50-75mgProviron daily for the last few weeks of dieting. Due to availability of Clenbuterol,Proviron dosages were reported lower as of late, at least in female fitness competitors.Women should be aware that birth control is an estrogen and Novladex will block itseffectiveness. Women have note irregular menstrual cycles, weaker menstrual bleeding,and sometimes skip periods all together during Nolvadex use. I know several women whouse Nolvadex for this reason and can not say I disagree with their choice. After all, theuse of progestin type birth control as a means of regulating or even stopping menstruationis becoming accepted in the medical circles at last.
A few athletes have experienced a paradox when using high dosages of Nolvadex.Instead of lowering estrogenic activity, it increased it. What happened was that theAdrenal glands went into over drive producing a pro-hormone called DHEA. DHEA isactually an adrenal androgen normally secreted in lower levels. As circulating levelsincreased enzymic factors came into play. Research shows DHEA readily converts intoandrostenedione, and to some extent, estrogens in males. (That sucks!) The femaleendocrine system usually favors testosterone production from converted DHEA orandrostenedione. The newly formed estrogen then overwhelmed the estrogen receptorsblocking the intended qualities of Novladex. In this case, Proviron, and especially Teslacwhere notably better choices.
*Gyno that fails to react to these drugs normally must be removed by surgery. DHTderivatives can cause increases endogenous estrogen production also in some individuals.Cytadren was a commonly co-administered drug with Nolvadex.

Reported Characteristics
Active-Life: Less than 24 hours Drug Class: Anti-estrogen/estrogen antagonist (Oral) Average Reported Dosage: 10-30-mg daily Acne: None Water Retention: No High Blood Pressure: Rare (not normally attributed to the drug itself) Liver Toxic: Yes

Arimidex (Anastrozole)

Arimidex Anastrozole Arimidex (Anastrozole) is what we call an aromatase inhibitor (AI). In clinical use, it´s used to halt the progression of Breast Cancer in women. It works by blocking the aromatase enzyme, which is responsible for the production of estrogen. In athletics and bodybuilding, it is used as an ancillary compound to be added to a cycle of Anabolic Steroids. In this respect it is also used for its estrogen reducing properties, but it has the additional benefit of increasing testosterone levels, as we´ll see... Arimidex Side EffectsMany anabolic steroids aromatize (convert to estrogen via the aromatase enzyme), and this is responsible for many of the unwanted side effects found with anabolic steroid use (acne, gynocomastia, water-retention, etc...). In one study, both .5mg and 1mg doses of Arimidex were shown to decrease estrogen by roughly 50%. The 1mg/day dose also increased testosterone levels by 58% (1). In that same study, in both groups, LH and FSH also went up slightly. Take a look: Changes in testosterone and E2 concentrations in normal young men (15 22 yr old) before () and after 10 days of oral anastrozole at 0.5 and 1 mg.(1) This would seem to suggest that for use during a cycle, a dose of .5mgs/day would be sufficient to combat estrogen-related side effects. It is, however, important to remember that some estrogen is necessary to obtain optimal muscle growth. The lower estrogen levels provided by ´dex seems, anecdotally at least, to produce a more "hard" and "quality" look for bodybuilders who have experimented with it´s use in either a cutting or bulking cycle. I´d like to point out that the elevation in Testosterone provided by Arimidex is so large that it can be used as a "form" of testosterone replacement therapy for hypogonadal men (2). Clearly, this suggests its use in a post-cycle-therapy (as well as its previously discussed use within a cycle) to regain natural testosterone levels and full functioning of the HPTA (Hypothalamic-Testicular-Pituitary-Axis). Literature provided by the original maker of Anastrozole (Arimidex, produced by Zeneca Pharmaceuticals) states that stable blood plasma concentrations of the compound are achieved after a mere 7 consecutive 1mg daily doses. Also, Arimidex is just over 80% effective at inhibiting aromatase (3). Thus, if you want to take it for the entire duration of a cycle of anabolic steroids, you can simply start taking it on the same day you begin your cycle. Those are some pretty good numbers, huh? But can you use it for the entire duration of a cycle? Is it dangerous? Well, certainly reducing estrogen levels in your body is good from a body building point of view, as it reduces water-retention and the potential for gynocomastia (if there´s no estrogen in your body, you can´t get gyno, regardless of how much progesterone is floating around)(5). Luckily this stuff is very mild on blood lipids (cholesterol) and doesn´t affect them adversely (2), in the studies I´ve seen. Arimidex and CholestrolAs previously mentioned, those lowered estrogen levels could possibly (eventually) adversely affect your cholesterol and possibly even your immune function. I am, however, very comfortable recommending Arimidex for relatively long-term use. This should be the ancillary compound of choice for those on long and heavy cycles, especially since it also doesn´t inhibit igf like some other ancillary compounds (insulin-like-growth-factor is an important component of anabolism)(4). Price of ArimidexThough price of Arimidex will vary, this is one of the compounds I will caution the reader from buying in its legitimate pharmaceutical form. The price (up to $5/tab) is absurd, when you consider its availability from Underground Labs, as well as in research form, for less than 1/3rd of that. I´ve used both the tabs from an Underground Lab, as well as the liquid version from research-sites, and found the results from both to be exactly the same. References: J Clin Endocrinol Metab 2000 Jul;85(7):2370-7, "Estrogen Suppression in Males" Clin Endocrinol (Oxf). 2005 Feb;62(2):228-35. Arimidex Package insert J Steroid Biochem Mol Biol. 2002 Apr;80(4-5):411-8. Progesterone is not essential to the differentiative potential of mammary epithelium in the male mouse. Freeman, Topper. Endocrinology. 1978 Jul;103(1):186-92