Wednesday, March 28, 2007

Equipoise (boldenone undecylenate)

Equipoise
Equipoise (boldenone undecylenate)


Quick overview:


Active Life: 14-16 days
Drug Class: Anabolic/Androgenic Steroid (for injection)
Average Dose: Men 400-600 mg/week......Women 50-150 mg/week
Acne: Rare
Water Retention: Low
High Blood Pressure: Rare
Liver Toxic: No
Aromatization: Some, about 50% less than testosterone
DHT Conversion: Low
Decrease HPTA function: Moderate


Equipoise® is the popular brand name for the veterinary injectable steroid boldenone undecylenate. It is a derivative of testosterone, which exhibits strong anabolic and moderately androgenic properties. The undecylenate ester greatly extends the activity of the drug (the undecylenate ester is only one carbon atom longer than decanoate), so that clinically injections would need to be repeated every three or four weeks. In the veterinary feild Equipoise is most commonly used on horses, exhibiting a pronounced effect on lean bodyweight, appetite and general disposition of the animal. As with all steroids, this compound shows a marked ability for increasing red blood cell production. In recent years this compound has become a favorite among athletes. Many consider it an ideal replacement to Deca-Durabolin.

The side effects of Equipoise are generally mild. The structure of boldenone does allow it to convert into estrogen, but it does not have an extremely high affinity to do so. If we look at aromatization studies, they suggest that its rate of estrogen conversion should be about half that of testosterone's. Water retention with this drug would therefore be slightly higher than that with Deca-Durabolin (with an estimated 20% conversion), but much less than we would find with a stronger compound as Testosterone. While there is still a chance of encountering an estrogen related side effect as such when using Equipoise, problems are usually not encountered at a moderate dosage level. Gynecomastia might become a problem, but usually only with very sensitive individuals or (again) with those using higher dosages. If estrogenic effects become a problem, the addition of Nolvadex should of course make the cycle more tolerable. An anti-aromatase such as Arimidex, Femara, or Amonasin would be a stronger option, however probably not necessary with such a mild drug.

Although typically dosage related, Equipoise can also produce distinct androgenic side effects. Oily skin, acne, increased aggression and hair loss are all possible with this compound. Women find this drug quite comfortable, virilization symptoms usually unheard of when taken at low doses. Boldenone does reduce to a more potent androgen (dihydroboldenone) via the 5alpha reductase enzyme (which produces DHT from testosterone), however its affinity for this interaction in the human body is low to nonexistent. Therefore the reductase inhibitor Proscar would not be of much use with Equipoise, as it would be blocking what is at best an insignificant path of metabolism for the steroid. Although this drug is relatively mild, it still has a depressive effect on endogenous testosterone levels, therefore a proper post cycle therapy HCG and Clomid/Nolvadex is needed at the conclusion of each cycle to avoid a "crash". A waiting time of around 3 weeks is required before starting PCT, enabling enough of the drug to clear one's system to make PCT effective.

In order to maintain stable blood levels, Equipoise should be injected at least once per week. It is most commonly used at a dosage of 400-600mg per week for men, 50-150 mg per week for women.

Equipoise is not a rapid mass builder, but will provide a slow but steady gain of strength and quality muscle mass. The most positive effects of this drug are seen when it is used for longer cycles, usually lasting at least 10 weeks in length. The muscle gained should not be the smooth bulk seen with androgens, but instead a very defined and solid look. Since water bloat is not contributing greatly to the diameter of the muscle, much of the size gained on a cycle of Equipoise can be retained after the drug has been discontinued. It is interesting to note that structurally Equipoise and the classic bulking drug Dianabol are almost identical. In the case of Equipoise the compound uses a l7beta ester (undecylenate), while Dianabol is 17 alpha alkylated. Aside from that difference, the drugs are basically the same. Of course they act quite differently in the body, which goes to show the 17-methylation effects more than just the oral efficancy of a steroid.

As discussed earlier, Equipoise is a very versatile compound. We can create a number of drug combinations with it depending on the desired result. For mass, one may want to stack it with Anadrol or an injectable testosterone. The result should be an incredible gain of muscle size and strength, without the same intensity of side effects if using the androgen (at a higher dose) alone. When used in a cutting cycle, muscle hardness and density can be greatly improved when combining Equipoise with a non-aromatizable steroid such as trenbolone acetate, Halotestin, or Winstrol. For some however, even the low buildup of estrogen associated with this compound is enough to relegate its use to bulking cycles only.

Equipoise is not an ideal steroid for the drug tested athlete however. This drug has the tendency to produce detectable metabolites in the urine months after use, a worry most commonly associated with Deca-Durabolin. This is of course due to the high oil solubility of long chain esterified injectable steroids, a property which enables the drug to remain deposited in fatty tissues for extended periods of time. While this will reliably slow the release of steroid into the blood stream, it also allows small residual amounts to remain present in the body far after the initial injection. The release of stubborn stores of hormone would no doubt also be enhanced around contest time, a period when the athlete drastically attempts to mobilize unwanted body fat. If enough were used in the off-season, the athlete may actually fail a drug screen for boldenone although many months may have past since the drug was last injected.

Sunday, March 25, 2007

Human Growth Hormone

Human Growth Hormone


Quick overview:


Active Life: Varies by injection method
Drug Class: Growth Hormone/IGF-1 Precursor (for injection)
Average Dose: Men 2-6 i.u. total daily
Acne: No
Water Retention: Rare
High Blood Pressure: Rare
Liver Toxic: No
Aromatization: No
Comments: High Anabolic/No Androgenic effects


In the human body growth hormone is produced by the pituitary gland. It exists at especially high levels during adolescence when it promotes the growth of tissues, protein deposition and the breakdown of subcutaneous fat stores. Upon maturation endogenous levels of GH decrease, but remain present in the body at a substantially lower level. In the body the actual structure of growth hormone is a sequence of 191 amino acids. Once scientists isolated this hormone, many became convinced it would exhibit exceptional therapeutic properties. It would be especially effective in cases of pituitary deficient dwarfism, the drug perhaps restoring much linear growth if administered during adolescence.

he 1980's brought about the first prepared drugs containing Human Growth Hormone. The content was taken from a biological origin, the hormone being extracted from the pituitary glands of human corpses then prepared as a medical injection. This production method was short lived however, since it was linked to the spread of a rare and fatal brain disease. Today virtually all forms of HGH are synthetically manufactured. The recombinant DNA process is very intricate; using transformed e-coli bacterial or mouse cell lines to genetically produce the hormone structure. It is highly unlikely you will ever cross the old biologically active item on the black market (such as Grorm), as all such products should now be discontinued. Here in the United States two distinctly structured compounds are being manufactured for the pharmaceutical market. The item Humatrope by Eli Lilly Labs has the correct 191 amino acid sequence while Genentech's Protropin has 192. This extra amino acid slightly increases the chance for developing an antibody reaction to the growth hormone. The 191 amino acid configuration is therefore considered more reliable, although the difference is not great. Protropin is still Anabolics 2002 considered an effective product and is prescribed regularly. Outside of the U.S., the vast majority of HGH in circulation will be the correct 191 amino acid sequence so this distinction is not a great a concern.

The use of growth hormone has been increasing in popularity among athletes, due of course to the numerous benefits associated with use. To begin with, GH stimulates growth in most body tissues, primarily due to increases in cell number rather than size. This includes skeletal muscle tissue, and with the exception of eyes and brain all other body organs. The transport of amino acids is also increased, as is the rate of protein synthesis. All of these effect are actually mediated by IGF-1 (insulin-like growth factor), a highly anabolic hormone produced in the liver and other tissues in response to growth hormone (peak levels of IGF-1 are noted approximately 20 hours after HGH administration). Growth hormone itself also stimulated triglyceride hydrolysis in adipose tissue, usually producing notable fat loss during treatment. GH also increases glucose output in the liver, and induces insulin resistance by blocking the activity of this hormone in target cells. A shift is seen where fats become a more primary source of fuel, further enhancing body fat loss.

Its growth promoting effect also seems to strengthen connective tissues, cartilage and tendons. This effect should reduce the susceptibility to injury (due to heavy weight training), and increase lifting ability (strength). HGH is also a safe drug for the "piss-test". Although its use is banned by athletic committees, there is no reliable detection method. This makes clear its attraction to (among others) professional bodybuilders, strength athletes and Olympic competitors, who are able to use this drug straight through a competition. There is talk however that a reliable test for the exogenous administration of growth hormone has been developed, and is close to being implemented. Until this happens, growth hormone will remain a highly sought after drug for the tested athlete.

But the degree in which HGH actually works for an athlete has been the topic of a long running debate. Some claim it to be the holy grail of anabolics, capable of amazing things. Able to provide incredible muscle growth and unbelievable fat loss in a very short period of time. Since it is used primarily by serious competitors who can afford such an expensive drug, a great body of myth further surrounds HGH discussion (among those personally unfamiliar). Many will state with the utmost confidence that the incredible mass of the Olympian competitors each year is 100% due to the use of HGH. Others have crossed bodybuilding materials claiming it to be a complete waste of money, an ineffective anabolic and barely worthwhile for fat loss. With its high price tag, certainly an incredibly poor buy in the face of steroids. So we have a very wide variety of opinions regarding this drug, whom should we believe?

It is first important to understand why there the results obtained from this drug seem to vary so much. A logical factor in this regard would seem to be the price of this drug. Due to the elaborate manufacturing techniques used to produce it, it is extremely costly. Even a moderately dosed cycle could cost an athlete between $75-$150 per daily dosage. Most are unable or unwilling to spend so much, and instead tinker around with low dosages of the drug. Most who have used this item extensively claim it will only be effective at higher doses. Poor results would then be expected if low amounts were used, or the drug not administered daily. If you cannot commit to the full expense of an HGH cycle, you should really not be trying to use the drug.

The average male athlete will usually need a dosage in the range of 4 to 6 I.U. per day to elicit the best results. On the low end perhaps 1 to 2 I.U. can be used daily, but this is still a considerable expense. Daily dosing is important, as HGH has a very short life span in the body. Peak blood concentrations are noted quickly (2 to 6 hours) after injection, and the hormone is cleared from the body with a half-life of only 20-30 minutes. Clearly it does not stick around very long, making stable blood levels difficult to maintain. The effects of this drug are also most pronounced when it is used for longer periods of time, often many months long. Some do use it for shorter periods, but generally only when looking for fat loss. For this purpose a cycle of at least four weeks would be used. This compound can be administered in both an intramuscular and subcutaneous injection. "Sub-Q" injections are particularly noted for producing a localized loss of fat, requiring the user to change injection points regularly to even out the effect. A general loss of fat seems to be the one characteristic most people agree on. It appears that the fat burning properties of this drug are more quickly apparent, and less dependent on high doses.

Other drugs also need to be used in conjunction with HGH in order to elicit the best results. Your body seems to require an increased amount of thyroid hormones, insulin and androgens while HGH levels are elevated (HGH therapy in fact is shown to lower thyroid and insulin levels). To begin with, the addition of thyroid hormones will greatly increase the thermogenic effectiveness of a cycle. Taking either Cytomel® or Synthroid® (prescription versions of T-3 and T-4) would seem to make the most sense (the more powerful Cytomel® is usually preferred). Insulin as well is very welcome during a cycle, used most commonly in an anabolic routine as described in this book under the insulin heading. Aside from replacing lowered insulin levels, use of this hormone is important as it can increase receptor sensitivity to IGF-1, and reduce levels of IGF binding protein-1 allowing for more free circulating IGF-1 (growth hormone itself also lowers IGF binding protein levelss'). Steroids as well prove very necessary for the full anabolic effect of GH to become evident. Particularly something with a notable androgenic component such as testosterone or trenbolone (if worried about estrogen) should be used. The added androgen is quite useful, as it promotes anabolism by enhancing muscle cell size (remember GH primarily effects cell number). Steroid use may also increase free IGF-1 via a lowering of IGF binding proteins. The combination of all of these (HGH, anabolics, insulin and T-3) proves to be the most synergistic combination, providing clearly amplified results. it is of course important to note that thyroid and insulin are particularly powerful drugs that involve a number of additional risks.

Release and action of GH and IGF-1: GHRH (growth hormone releasing hormone) and SST (somatostatin) are released by the hypothalamus to stimulate or inhibit the output of GH by the pituitary. GH has direct effects on many tissues, as well as indirect effects via the production of IGF-1. IGF-1 also causes negative feedback inhibition at the pituitary and hypothalamus. Heightened release of somatostatin affects not only the release of GH, but insulin and thyroid hormones as well.

HGH itself does carry with it some of its own risks. The most predominantly discussed side effect would be acromegaly, or a noticeable thickening of the bones (notably the feet, forehead, hands, jaw and elbows). The drug can also enlarge vital organs such as the heart and kidney, and has been linked to hypoglycemia and diabetes (presumably due to its ability to induce insulin resistance). Theoretically, overuse of this hormone can bring about a number of conditions, some life threatening. Such problems however are extremely rare. Among the many athletes using growth hormone, we have very few documented cases of a serious problem developing. When used periodically at a moderate dosage, the athlete should have little cause for worry. Of course if there are any noticeable changes in bone structure, skin texture or normal health and well being during use, HGH therapy should be completely halted.

In summary, the biggest mistake we can make with this drug is to get confused by the price tag. Even a relatively short cycle of this drug (and ancillaries) will cost in the thousand(s), not hundreds of dollars. We cannot jump to the conclusion that GH is therefore the most unbelievable anabolic. This hormone is simply very complex, and costly to manufacture (though it should be getting cheaper). If you were looking to achieve just a great mass gain the $1,000 would be better spent on steroids. Growth Hormone will not turn you into an overnight "freaky" monster and it is certainly not "the answer". Yes, it is a very effective performance enhancement tool. But it is more a tool for the competitive athlete looking for more than steroids alone can provide. There is little doubt that GH contributes considerably to the physiques and performance of many top bodybuilders and athletes. In this arena, the money spent on it is well justified, the drug obviously necessary. But outside of competitive sports it is usually not.

Friday, March 16, 2007

Cytomel® (liothyronine sodium)

Cytomel ® (liothyronine sodium)


Quick overview:
Drug Class: Synthetic thyroid hormoneAverage Dose: 25-100 mcg/dayComments: Significant suppression of Thyroid function during use


Cytomel® is the popularly recognized brand name for the drug liothyronine sodium. This is not an anabolic steroid but a thyroid hormone. It is used medically to treat cases of thyroid insufficiency, obesity, certain metabolic disorders and fatigue. Specifically this drug is a pharmaceutical preparation of the natural thyroid hormone triiodothyronine (T-3). When administered, Cytomel increases the patient's metabolism. The result is an increased rate of cellular activity (noted by a more rapid utilization of carbohydrates, fats and proteins). Bodybuilders are particularly attracted to this drug for its ability to burn off body excess fat. Most often utilized during contest preparation, one can greatly decrease the amount of stored fat without being forced to severely restrict calories. To this end Cytomel is commonly used in conjunction with Clenbuterol and can produce extremely dramatic results. This combination has become very popular in recent years, no doubt responsible for many "ripped" on-stage physiques. It is also noted by many that when thyroid hormones are taken in conjunction with steroids, an increased anabolic effect can be seen (noticeably greater than if the steroids are used alone). This is likely due to faster utilization of proteins by the body, increasing the rate for new muscle accumulation.


Caution should be taken if one is considering using this drug. Cytomel comes with an extensive list of warnings and precautions which are not to be ignored. Side effects include, but are not limited to, heart palpitations, agitation, shortness of breath, irregular heartbeat, sweating, nausea, headaches, and psychic/metabolic disorders. It is a powerful hormone, and one that could potentially alter the normal functioning of the body if misused. When taking Cytomel, one must remember to increase the dosage slowly. Generally one 25mcg tablet is taken on the first day, and the dosage is thereafter increased by one tablet every three of four days for a maximum dosage of 100mcg. This will help the body adjust to the increased thyroid hormone, hopefully avoiding any sudden "shock" to the system. The daily dose should also be split evenly throughout the day, in an effort to keep blood levels steadier. Women are more sensitive to the side effects of Cytomel than men, and usually choose not to take no more than 50mcg daily.
It is important to stress that a cycle should last no longer than 6 weeks and it should never be halted abruptly. As slowly as the dosage was built up it should also be lowered, one tablet every 3-4 days. Taking Cytomel for too long and/or at too high a dosage can result in a permanent thyroid deficiency. After doing such, one might need to be treated with a drug like Cytomel for life. It is also a good idea to first consult your physician and have your thyroid function tested. An undiagnosed hyperfunction would not mix well with the added hormone. An athlete should also be sure never to purchase an injectable form of the drug. It is generally an emergency room product, much too powerful for athletic use. Since T-3 is the most powerful thyroid hormone athletes are using, this is generally not the starting point for a beginner. Before using such a powerful item, it is a good idea to become familiar with a weaker substance. The highly popular Triacana is very mild, allowing the user much more latitude (from severe side effects) than Cytomel. An in-between point is Synthroid (synthetic T-4), still weaker in action than Cytomel. Once the user is ready however, the fat burning effect of this hormone can be extremely dramatic.

Saturday, March 10, 2007

Deca-Durabolin® (nandrolone decanoate)

Deca-Durabolin® (nandrolone decanoate)


Quick overview:


Active Life: 14-16 days
Drug Class: Anabolic/Androgenic Steroid (injectable)
Average Dose: Men 300-800 mg/week.....Women 50-100 mg/week
Acne: Yes, in higher dosages or sensitive individuals
Water Retention: Yes, but less than testosterone
High Blood Pressure: Dose depandant
Liver Toxic: No
Aromatization: Low, converts to less active norestrogens
DHT Conversion: No, converts to NOR-DHT with low activity
Decrease HPTA function: Yes, extreme
Other Info: Highly anabolic/moderate androgenic effects


Deca-Durabolin® is the Organon brand name for the injectable steroid nandrolone decanoate. This compound came around early in the wave of commercial steroid development, first being made available as a prescription medication in 1962.

World wide "Deca" is one of the most widely used anabolic steroids. Its popularity is due to the simple fact that it exhibits many very favorable properties. Structurally nandrolone is very similar to testosterone, although it lacks a carbon atom at the 19th position (hence its other name 19-nortestosterone). The resulting structure is a steroid that exhibits much weaker androgenic properties than testosterone. Of primary interest is the fact that nandrolone will not break down to a more potent metabolite in androgen target tissues. You may remember this is a significant problem with testosterone. Although nandrolone does undergo reduction via the same (5-alpha reductase) enzyme that produces DHT from testosterone, the result in this case is dihydronandrolone. This metabolite is weaker than the parent nandroloness, and is far less likely to cause unwanted androgenic side effects. Strong occurrences of oily skin, acne, body/facial hair growth and hair loss occur very rarely. It is however possible for androgenic activity to become apparent with this as any steroid, but with nandrolone higher than normal doses are usually responsible.

Nandrolone also show an extremely lower tendency for estrogen conversion. For comparison, the rate has been estimated to be only about 20% of that seen with testosterones. This is because while the liver can convert nandrolone to estradiol, in other more active sites of steroid aromatization such as adipose tissue nandrolone is far less open to this process'. Consequently estrogen related side effects are a much lower concern with this drug. An anti-estrogen is likewise rarely needed with Deca, gynecomastia only a worry among sensitive individuals. At the same time water retention is not a usual concern. This effect can occur however, but is most often related to higher dosages. The addition of Proviron and/or Nolvadex should prove sufficient enough to significantly reduce any occurrence. Clearly Deca is a very safe choice among steroids. Actually, many consider it to be the best overall steroid for a man to use when weighing the side effects and results. It should also be noted that in HIV studies, Deca has been shown not only to be effective at safely bringing up the lean body weight of patient, but also to be beneficial to the immune system.

It is of note however that nandrolone is believed to have some activity as a progestin in the body. Although progesterone is a c-19 steroid, removal of this group as in 19-norprogesterone creates a hormone with greater binding affinity for its corresponding receptor. Sharing this trait, many 19-nor anabolic steroids are shown to have some affinity for the progesterone receptor as well. This can lead to some progestin-like activity in the body, and may intensify related side effects. The side effects associated with progesterone are actually quite similar to those of estrogen, including negative feedback inhibition of testosterone production, enhanced rate of fat storage and possibly gynecomastia. Many believe the progestin activity of Deca notably contributes to suppression of testosterone synthesis, which can be marked despite a low tendency for estrogen conversion.

Deca is not known as a very "fast" builder. The muscle building effect of this drug is quite noticeable, but not dramatic. The slow onset and mild properties of this steroid therefore make it more suited for cycles with a longer duration. In general one can expect to gain muscle weight at about half the rate of that with an equal amount of testosterone. A cycle lasting eight to twelve weeks seems to make the most sense, expecting to elicit a slow, even gain of quality mass. Although active in the body for much longer, Deca is usually injected once or twice per week. The dosage for men is usually in the range of 300-600mg/week. If looking to be specific, it is believed that Deca will exhibit its optimal effect (best gain/side effect ratio) at around 2mg per pound of lean bodyweight/weekly. Deca is also a popular steroid among female bodybuilders. They take a much lower dosage on average than men of course, usually around 50mg weekly. Although only slightly androgenic, women are occasionally confronted with virilization symptoms when taking this compound. Should this become a concern, the shorter acting nandrolone Durabolin would be a safer option. This drug stays active for only a few days, greatly reducing the impact of androgenic buildup if withdrawal were indicated.

Endogenous testosterone levels can be a concern with Deca-Durabolin, especially after long cycles. It is therefore mandatory to incorporate ancillary drugs at the conclusion of therapy. An estrogen antagonist such as Clomid or Nolvadex is therefore commonly used for a few weeks. These both provide a good level of testosterone stimulation, although they may take a couple of weeks to show the best effect. HCG injections could be added for extra reassurance, acting to rapidly restore the normal ability of the testes to respond to the resumed release of gonadotropins. For this purpose one could administer three injections of 2500-50001.U., spaced five days apart. After which point the antagonist is continued alone for a few more weeks in an effort to stabilize the production of testosterone. Remember not to begin post cycle therapy (PCT) until after Deca has been withdrawn for around three weeks. Deca stays active for quite some time so the ancillary drugs will not be able to exhibit their optimal effect when the steroid is still being released into the bloodstream. The major drawback for competitive purposes is that in many cases nandrolone metabolites will be detectable in a drug screen for up to a year (or more) after use. This is clearly due to the form of administration. Esterified compounds have a high affinity to stay stored in fatty tissues. While we can accurately estimate the time frame it will take for a given dose to enter circulation from an injection site, we cannot know for sure that 100% of the steroid will have been metabolized at any given point. Small amounts may indeed be stubborn in leaving fatty tissue, particularly after heavy, longer-term use. Some quantity of nandrolone decanoate may therefore be left to sporadically enter into the blood stream many months after use. This process may be further aggravated when dieting for a show, a time when body fat stores are being actively depleted (possibly freeing more steroid). This has no doubt been the cause for many unexpected positives on a drug screen. The fact that nandrolone has been isolated as the "hands-off" injectable for the drug tested athlete is most likely due to its popularity (and therefore common appearance on drug screens). The same risk would of course hold true for other long chain esterified injectables such as Equipoise, and Primobolan.

Those not worried about drug screens are likely to find the low water retention and good effect of this drug favorable for use in pre-contest cutting stacks. A combination of Deca and Winstrol during the weeks/months leading up to a show for example, is noted to greatly enhance to look of muscularity and definition. A strong non-aromatizing androgen like Halotestin or trenbolone could be further added, providing an enhanced level of hardness and density to the muscles. Being an acceptable anabolic, Deca can also be incorporated into bulk cycles with good results. The classic Deca and Dianabol cycle has been a basic for decades, and always seems to provide excellent muscle growth. A stronger androgen such as Anadrol or testosterone could also be substituted, producing greater results. When mixed with Deca, the androgen dosage can be kept lower than if used alone, hopefully making the cycle more comfortable. Additionally one may choose to continue Deca for a number of few weeks after the androgen has been stopped. This will hopefully harden up some of the bloat produced by the androgen, giving a more quality appearance. Remember that endogenous testosterone production will not resume during Deca therapy, and ancillaries are likewise still needed.

Thursday, March 8, 2007

Omnadren 250

Omnadren 250 (4-Testosterone Ester Blend)


Omnadren is a mixture of 4 Testosterones: 60-mg Testosterone Phenylpropionate 30-mg Testosterone Propionate 60-mg Testosterone Isohexanoate 100-mg Testosterone Hexanoate
Omnadren 250 is very popular because it is similar to Sustanon 250 but is a little cheaper in most cases Omnadren is similar to Sustanon (it was the second 4-testosterone blend on the marked), and is only different from Sustanon in that Omnadren contains Testosterone Isohexanoate and Testosterone Hexanoate, instead of Testosterone Decanoate and Isocaproate. This gave omnadren 250Omnadren a proclivity towards higher water retention rating and aromatization factor over Sustanon.The comparison is, however, still very appropriate. Counterfeit Sustanon was often simply the much cheaper test blend Omnadren.


Omnadren provides the same fast weight gain and strength build-up of any other long-estered testosterone. Unfortunately,it can also give the user a bloated appearance if an aromatase-inhibitor (such as exemestane) is not used. Typical reports from Omnadren users include increased pump, appetite, and training aggressiveness as well as an enhanced sex drive. Acne, Hairloss, and water retention are also reported, unfortunately.


Omnadren is clearly both very androgenic and vey anabolic. It is generally only considered appropriate for bulking cycles where mass and strength build-ups were desired. Commonly, it is stacked with Deca-Durabolin or Equipoise, and/or Anadrol.


Reported Characteristics
Pharmaceutical Name:Testosterone Chemical Name:4-androsten-3-one-17b-ol Cutting/Bulking:Bulking Anabolic Rating:100 Active Life: About 18 days total Drug Class: Androgenic/Anabolic Steroid (For injection) Average Reported Dosage: 125-1500MG weekly (males only) Acne: Yes Water Retention: Yes High Blood Pressure: Yes Liver Toxic: Low, except in high dosages Aromatization: Yes DHT Conversion: Yes, high Decreases HPTA function: Yes Average Price: $8/per amp

Monday, March 5, 2007

Anadrol - Oxymetholone

anadrol 50 information


Anadrol - Oxymetholone



Steroid Profiles - Anadrol - Oxymetholone

This is an oral, methylated (17-alpha-alkylated) steroid that is both highly androgenic as well as highly anabolic. Some novice users report weight gains of up to a pound per day fpor the first 3 weeks of administration, as well as incredible strength gains. Neither is uncommon among first-time steroid users, and this type of weight gain makes Anadrol one of the most highly coveted drugs for off season mass-building cycles. Aggressiveness often increases dramatically on this compound, and that may be due to the elevation in androgen levels it provides, it's effects on the central nervous system, and it being derived from DHT (Dihydrotestosterone), which anecdotally seems to make athletes much more agressive. This last effect is often seen by the media as a negative side effect, but in a hard training (and emotionally stable) athlete, this aggressiveness often manifests itself as a stronger drive in the gym and results in more strength gained, and ultimately, more weight. Unfortunately, users of this drug also experience the negative aspects of DHT which can include excessive water retention, acne, and hairloss.
Anadrol 50 tablets by British Dragon Many people consider Anadrol a dangerous compound, but this isn't necessarily so. Anadrol was originally produced in a whopping 50mg pill, so you don't need to take many of them to get a very high dose of Oxymetholone (the drug in Anadrol). Compare this dose to Anavar which is produced in a 2.5mg pill, or Dianabol which was produced in a 5mg pill, and you'll see why Anadrol has such a reputation for being powerful. One tab is has as many milligrams as 20 of the original Anavar tabs or 20 of the original Dianabol tabs! On a milligram for milligram basis, Anadrol is no more dangerous than most oral steroids out there. You just have to remember that you get 50mgs in each tablet, and adjust your dose accordingly. Occasionally people using Anadrol get flu-like-symptoms or a headache. I personally get both, but the headache is much worse (it is probably from my bloodpressure elevating quickly). Alot of the horror stories you hear about steroids is from people abusing this one in particulat. Chris Duffy ( a now retired IFBB professional) claimed to use ten of them every day. It's no wonder that it has been linked to prostate and liver cancer, liver disease, thyroid dysfunction, leukemia, and heart disorders, and even hepatic comas. Again, this is a powerful drug, and not to be taken lightly, but is no more dangerous than many others. It will also raise your hematocrit, and commesurately your blood pressure. to where clotting time may become an issue. Since Anadrol is derived from DHT, it can cause issues in DHT-sensitivce target tissure like the scalp, prostate, and sebaceous glands. It can also cause suppression of the Hypothalamic-Pituitary-Testicular-Axis, resulting in a low sperm count, and a lowering of Leutenizing hormone, which is what signals your testes to secrete testosterone. Anadrol therapy, therefore, will lower your testosterone levels.




Women generally steer clear of Anadrol, because of it's possible virilizing effects, including clitoral enlargement, facial hair growth, deeper voice, and missed periods..
Oxymetholone is infamous for negatively effecting liver function and increasing markers of that such as SGPT and SGOT enzymes (and others) which are all hepatic indicators (indicators of liver dysfunction). Jaundice (a yellowing of the whites of the eyes and finger nails) can even occur from extended Anadrol use. As previously stated, Anadrol is a derivative of DHT, which is itself a 5-alpha-reduced version of testosterone. Some androl users have reported gyno from its use but this is unlikely to be a result of anadrol (which doesn't convert to estrogen, nor DHT, nor can it stimulate the progesterone receptor). Users of Anadrol who experience gynocomastia (the of breast tissue by males) have probably developed this condition as a result of the concurrent use of another steroid along with their Anadrol. Oxymetholone also causes edema (water retention) which could possibly be due to enhanced retention, which often causes a smoothe appearance to muscles.




Andarol'is medical use is (as with most steroids) to treat low red blood cell production, which often manifests itself as aenemia. Therefore, during administration of Anadrol, red blood cell count is increased greatly. For the hard-training athlete, this is a great benefit bnecause it meant that there is more oxygen transported to the muscles, resulting in both an incredible muscle pump as well as increased ability to do multiple sets with very heavy weights. The time needed between sets, and ability to do more sets per workout are both increased, and a reduced need for off-days from the gym is often seen as well. This increased work capacity contributes to the athlete being able to do a great deal more productive weight training sessions per cycle, and this of course contributes to their gains immeasurably.




Advanced bodybuilders and power lifters have reported excellent results with 50-200 mg per day, taken in divided doses. It's very often the drug of choice for athletes attempting to move up a weight class in bodybuilding or powerlifting. Although myself and many others have used Anadrol alone, it's not very common to do so, and it's generally stacked with something like Testosterone, and Deca Durabolin or Equipoise. By stacking it with highly anabolic compounds like them, more high quality gains are generally seen, and less of the watery/bloated look is experienced.

Reported Characteristics
Pharmaceutical Name:Oxymetholone



Chemical name:17-beta-hydroxy-2-hydroxymethylene-17 alpha-methyl-5 alpha-androstan-3-one Cutting/Bulking:



Bulking Anabolic Rating:320 Active - Life: Less than 16 hours



Drug Class: Highly Androgenic / Anabolic Steroid (Oral)



Average Reported Dosage: Men 50-200 mg daily. Acne: Yes Water Retention: Extreme High Blood Pressure: Yes



Liver Toxic: High



DHT Conversions: DHT-Derived



Decreases HPTA Function: Yes



Aromatization: No



Average Price: Up to $3/tab

TRADE NAMES
ANAPOLON 100 100mg tabs ANAPOLON 50 ANADROL-50 50 MG TABS ANAPOLON 5, 50 MG TABS HEMOGENIN 50 MG TABS SYNASTERON 50 MG TABS OXYMETHOLONE USP XXII 50 MG TABS

Friday, March 2, 2007

Human Growth Hormone

Human Growth Hormone


Quick overview:


Active Life: Varies by injection method
Drug Class: Growth Hormone/IGF-1 Precursor (for injection)
Average Dose: Men 2-6 i.u. total daily
Acne: No
Water Retention: Rare
High Blood Pressure: Rare
Liver Toxic: No
Aromatization: No
Comments: High Anabolic/No Androgenic effects


In the human body growth hormone is produced by the pituitary gland. It exists at especially high levels during adolescence when it promotes the growth of tissues, protein deposition and the breakdown of subcutaneous fat stores. Upon maturation endogenous levels of GH decrease, but remain present in the body at a substantially lower level. In the body the actual structure of growth hormone is a sequence of 191 amino acids. Once scientists isolated this hormone, many became convinced it would exhibit exceptional therapeutic properties. It would be especially effective in cases of pituitary deficient dwarfism, the drug perhaps restoring much linear growth if administered during adolescence.

he 1980's brought about the first prepared drugs containing Human Growth Hormone. The content was taken from a biological origin, the hormone being extracted from the pituitary glands of human corpses then prepared as a medical injection. This production method was short lived however, since it was linked to the spread of a rare and fatal brain disease. Today virtually all forms of HGH are synthetically manufactured. The recombinant DNA process is very intricate; using transformed e-coli bacterial or mouse cell lines to genetically produce the hormone structure. It is highly unlikely you will ever cross the old biologically active item on the black market (such as Grorm), as all such products should now be discontinued. Here in the United States two distinctly structured compounds are being manufactured for the pharmaceutical market. The item Humatrope by Eli Lilly Labs has the correct 191 amino acid sequence while Genentech's Protropin has 192. This extra amino acid slightly increases the chance for developing an antibody reaction to the growth hormone. The 191 amino acid configuration is therefore considered more reliable, although the difference is not great. Protropin is still Anabolics 2002 considered an effective product and is prescribed regularly. Outside of the U.S., the vast majority of HGH in circulation will be the correct 191 amino acid sequence so this distinction is not a great a concern.

The use of growth hormone has been increasing in popularity among athletes, due of course to the numerous benefits associated with use. To begin with, GH stimulates growth in most body tissues, primarily due to increases in cell number rather than size. This includes skeletal muscle tissue, and with the exception of eyes and brain all other body organs. The transport of amino acids is also increased, as is the rate of protein synthesis. All of these effect are actually mediated by IGF-1 (insulin-like growth factor), a highly anabolic hormone produced in the liver and other tissues in response to growth hormone (peak levels of IGF-1 are noted approximately 20 hours after HGH administration). Growth hormone itself also stimulated triglyceride hydrolysis in adipose tissue, usually producing notable fat loss during treatment. GH also increases glucose output in the liver, and induces insulin resistance by blocking the activity of this hormone in target cells. A shift is seen where fats become a more primary source of fuel, further enhancing body fat loss.

Its growth promoting effect also seems to strengthen connective tissues, cartilage and tendons. This effect should reduce the susceptibility to injury (due to heavy weight training), and increase lifting ability (strength). HGH is also a safe drug for the "piss-test". Although its use is banned by athletic committees, there is no reliable detection method. This makes clear its attraction to (among others) professional bodybuilders, strength athletes and Olympic competitors, who are able to use this drug straight through a competition. There is talk however that a reliable test for the exogenous administration of growth hormone has been developed, and is close to being implemented. Until this happens, growth hormone will remain a highly sought after drug for the tested athlete.

But the degree in which HGH actually works for an athlete has been the topic of a long running debate. Some claim it to be the holy grail of anabolics, capable of amazing things. Able to provide incredible muscle growth and unbelievable fat loss in a very short period of time. Since it is used primarily by serious competitors who can afford such an expensive drug, a great body of myth further surrounds HGH discussion (among those personally unfamiliar). Many will state with the utmost confidence that the incredible mass of the Olympian competitors each year is 100% due to the use of HGH. Others have crossed bodybuilding materials claiming it to be a complete waste of money, an ineffective anabolic and barely worthwhile for fat loss. With its high price tag, certainly an incredibly poor buy in the face of steroids. So we have a very wide variety of opinions regarding this drug, whom should we believe?

It is first important to understand why there the results obtained from this drug seem to vary so much. A logical factor in this regard would seem to be the price of this drug. Due to the elaborate manufacturing techniques used to produce it, it is extremely costly. Even a moderately dosed cycle could cost an athlete between $75-$150 per daily dosage. Most are unable or unwilling to spend so much, and instead tinker around with low dosages of the drug. Most who have used this item extensively claim it will only be effective at higher doses. Poor results would then be expected if low amounts were used, or the drug not administered daily. If you cannot commit to the full expense of an HGH cycle, you should really not be trying to use the drug.

The average male athlete will usually need a dosage in the range of 4 to 6 I.U. per day to elicit the best results. On the low end perhaps 1 to 2 I.U. can be used daily, but this is still a considerable expense. Daily dosing is important, as HGH has a very short life span in the body. Peak blood concentrations are noted quickly (2 to 6 hours) after injection, and the hormone is cleared from the body with a half-life of only 20-30 minutes. Clearly it does not stick around very long, making stable blood levels difficult to maintain. The effects of this drug are also most pronounced when it is used for longer periods of time, often many months long. Some do use it for shorter periods, but generally only when looking for fat loss. For this purpose a cycle of at least four weeks would be used. This compound can be administered in both an intramuscular and subcutaneous injection. "Sub-Q" injections are particularly noted for producing a localized loss of fat, requiring the user to change injection points regularly to even out the effect. A general loss of fat seems to be the one characteristic most people agree on. It appears that the fat burning properties of this drug are more quickly apparent, and less dependent on high doses.

Other drugs also need to be used in conjunction with HGH in order to elicit the best results. Your body seems to require an increased amount of thyroid hormones, insulin and androgens while HGH levels are elevated (HGH therapy in fact is shown to lower thyroid and insulin levels). To begin with, the addition of thyroid hormones will greatly increase the thermogenic effectiveness of a cycle. Taking either Cytomel® or Synthroid® (prescription versions of T-3 and T-4) would seem to make the most sense (the more powerful Cytomel® is usually preferred). Insulin as well is very welcome during a cycle, used most commonly in an anabolic routine as described in this book under the insulin heading. Aside from replacing lowered insulin levels, use of this hormone is important as it can increase receptor sensitivity to IGF-1, and reduce levels of IGF binding protein-1 allowing for more free circulating IGF-1 (growth hormone itself also lowers IGF binding protein levelss'). Steroids as well prove very necessary for the full anabolic effect of GH to become evident. Particularly something with a notable androgenic component such as testosterone or trenbolone (if worried about estrogen) should be used. The added androgen is quite useful, as it promotes anabolism by enhancing muscle cell size (remember GH primarily effects cell number). Steroid use may also increase free IGF-1 via a lowering of IGF binding proteins. The combination of all of these (HGH, anabolics, insulin and T-3) proves to be the most synergistic combination, providing clearly amplified results. it is of course important to note that thyroid and insulin are particularly powerful drugs that involve a number of additional risks.

Release and action of GH and IGF-1: GHRH (growth hormone releasing hormone) and SST (somatostatin) are released by the hypothalamus to stimulate or inhibit the output of GH by the pituitary. GH has direct effects on many tissues, as well as indirect effects via the production of IGF-1. IGF-1 also causes negative feedback inhibition at the pituitary and hypothalamus. Heightened release of somatostatin affects not only the release of GH, but insulin and thyroid hormones as well.

HGH itself does carry with it some of its own risks. The most predominantly discussed side effect would be acromegaly, or a noticeable thickening of the bones (notably the feet, forehead, hands, jaw and elbows). The drug can also enlarge vital organs such as the heart and kidney, and has been linked to hypoglycemia and diabetes (presumably due to its ability to induce insulin resistance). Theoretically, overuse of this hormone can bring about a number of conditions, some life threatening. Such problems however are extremely rare. Among the many athletes using growth hormone, we have very few documented cases of a serious problem developing. When used periodically at a moderate dosage, the athlete should have little cause for worry. Of course if there are any noticeable changes in bone structure, skin texture or normal health and well being during use, HGH therapy should be completely halted.

In summary, the biggest mistake we can make with this drug is to get confused by the price tag. Even a relatively short cycle of this drug (and ancillaries) will cost in the thousand(s), not hundreds of dollars. We cannot jump to the conclusion that GH is therefore the most unbelievable anabolic. This hormone is simply very complex, and costly to manufacture (though it should be getting cheaper). If you were looking to achieve just a great mass gain the $1,000 would be better spent on steroids. Growth Hormone will not turn you into an overnight "freaky" monster and it is certainly not "the answer". Yes, it is a very effective performance enhancement tool. But it is more a tool for the competitive athlete looking for more than steroids alone can provide. There is little doubt that GH contributes considerably to the physiques and performance of many top bodybuilders and athletes. In this arena, the money spent on it is well justified, the drug obviously necessary. But outside of competitive sports it is usually not.